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KMID : 0360119960180020316
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
1996 Volume.18 No. 2 p.316 ~ p.322
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The effects of sodium fluroide on squamous cell carcioma cell line cultured in vitro
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Abstract
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The effects of Sodium Fluoride on squamous cell carcinoma cell line(SCC-cells) cultured in vitro have been studied with respect to cytotoxicity and induction of chromosome aberrations.
Cytotoxicity of NaF on SCC-cells, as determined by a decrease in colony-forming ability, linearly increased with dose of NaF(150-300 ㎍/ml) or exposure time (3-24h).
SCC-cells treated with 30-60ug/ml NaF for 24h were analyzed for chromosome aberrations. A significant increase in the frequency of chromosome aberration at the chromatid level was induced by NaF in a dose-dependent manner.
These results suggest that NaF is a toxic substance which inhibit cell proliferation and causes DNA damage in SCC-cells cultured in Vitro.
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